Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

Akira Endo, Masao Kuroda, Yoshio Tsujita · The Journal of Antibiotics · 1976 · 954 citations · Full text

Life Sciences, Microbiology, Drug Discovery +2

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

Akira Endo, Masao Kuroda, Kazuhiko Tanzawa · FEBS Letters · 1976 · 802 citations

Life Sciences, Biochemistry, Pharmacology +16

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

Michael S. Brown, J R Faust, Joseph L. Goldstein et al. · Journal of Biological Chemistry · 1978 · 557 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

Cholesterol 7α-hydroxylase

N. B. Myant, Konstantinos Mitropoulos · Journal of Lipid Research · 1977 · 518 citations · Full text

Inhibition of Cholesterol Synthesis <i>in vitro</i> and <i>in vivo</i> by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

Akira Endo, Yoshio Tsujita, Masao Kuroda et al. · European Journal of Biochemistry · 1977 · 263 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14