Low frequency of CYP2D6 poor metabolizers among schizophrenia patients

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

Inger Johansson, Mikael Oscarson, Qun‐Ying Yue et al. · Molecular Pharmacology · 1994 · 430 citations

Medicine, Genetics, Molecular Genetics +16

Dopamine Formation from Tyramine by CYP2D6

Toyoko Hiroi, Susumu Imaoka, Yoshihiko Funae · Biochemical and Biophysical Research Communications · 1998 · 235 citations

Medicine, Pharmacokinetics, Pharmacology +12

The impact of the <i>CYP2D6</i> polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment

Jürgen Brockmöller, Julia Kirchheiner, Jürgen Schmider et al. · Clinical Pharmacology & Therapeutics · 2002 · 202 citations

Medicine, Pharmacology, Psychiatry +17

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

Ai‐Ming Yu, Jeffrey R. Idle, Linda G. Byrd et al. · PubMed · 2003 · 160 citations

Medicine, Neuroscience, Pharmacology +17

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics

Sharon Miksys, Yushu Rao, Ewa Hoffmann et al. · Journal of Neurochemistry · 2002 · 151 citations

Life Sciences, Neuroscience, Pharmacology +14