Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents

Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules

Gilles Klopman · Journal of the American Chemical Society · 1984 · 428 citations

Pharmacy, Chemistry, Medicinal Chemistry +11

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

Chii M. Lin, Holly H. Ho, George R. Pettit et al. · Biochemistry · 1989 · 414 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol^,

Ernst ter Haar, Richard Kowalski, Ernest Hamel et al. · Biochemistry · 1996 · 381 citations

Medicine, Oncology, Pharmacology +17

MULTICASE 1. A Hierarchical Computer Automated Structure Evaluation Program

Gilles Klopman · Quantitative Structure-Activity Relationships · 1992 · 314 citations

Pharmacy, Medicinal Chemistry, Computational Chemistry +12

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

Mark Cushman, Dhanapalan Nagarathnam, Dhanushya Gopal et al. · Journal of Medicinal Chemistry · 1991 · 299 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9