Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

J Michael Kilby, Sam Hopkins, Thomas M. Venetta et al. · Nature Medicine · 1998 · 991 citations

Human Retrovirus, Immunology, Antiviral Response +10

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

Quentin J. Sattentau, John P. Moore · The Journal of Experimental Medicine · 1991 · 598 citations · Full text

Virus Structure, Viral Replication, Human Immunodeficiency Virus +15

Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents

Yoshiki Kashiwada, Fumio Hashimoto, L. Mark Cosentino et al. · Journal of Medicinal Chemistry · 1996 · 272 citations · Full text

Pharmaceutical Science, Altmetric Attention Score, Pharmacotherapy +16

Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-<i>O</i>-(3′,3′-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection

Patrick F. Smith, Abayomi Ogundele, Alan Forrest et al. · Antimicrobial Agents and Chemotherapy · 2007 · 192 citations · Full text

Betulinic Acid Derivatives:  A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry

Françoise Soler, Christèle Poujade, Michel Evers et al. · Journal of Medicinal Chemistry · 1996 · 126 citations

Bioorganic Chemistry, Immunology, Molecular Biology +22