1173C>T Polymorphism in VKORC1 Modulates the Required Warfarin Dose

Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

Guruprasad P. Aithal, Christopher P. Day, Patrick Kesteven et al. · The Lancet · 1999 · 1.2K citations

Medicine, Pharmacokinetics, Pharmacology +12

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Simone Rost, Andreas Fregin, Vytautas Ivaškevičius et al. · Nature · 2004 · 1.1K citations

Medicine, Genetics, Molecular Genetics +12

A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin

Giovanna D’Andrea, Rosa D’Ambrosio, P Perna et al. · Blood · 2004 · 695 citations · Full text

Medicine, Genetics, Pharmacology +14

The Risk for and Severity of Bleeding Complications in Elderly Patients Treated with Warfarin

Stephan D. Fihn · Annals of Internal Medicine · 1996 · 560 citations

Medicine, Geriatric Medicine, Pharmacotherapy +17

Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9

Allan E. Rettie, Larry C. Wienkers, Frank J. Gonzalez et al. · Pharmacogenetics · 1994 · 493 citations

Medicine, Molecular Genetics, Pharmacology +10