Concepedia

The mechanism of geranylgeraniol-induced apoptosis involves activation, by a caspase-3-like protease, of a c-Jun N-terminal kinase signaling cascade and differs from mechanisms of apoptosis induced by conventional chemotherapeutic drugs

Yutaka Masuda, Mie Nakaya, Toshihiro Aiuchi, Sachiko Hashimoto, Shigeo Nakajo, Kazuyasu Nakaya

Leukemia Research · 2000 · 23 citations · 45 references

DOI

Concepts

References

45

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Zhengui Xia, Martin Dickens, Joël Raingeaud et al. · Science · 1995 · 5.3K citations

, , +16

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

, , +13

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Benoit Dérijard, Masahiko Hibi, I‐Huan Wu et al. · Cell · 1994 · 3.2K citations

, , +10

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

Jiahuai Han, Jeffrey Lee, L. Bibbs et al. · Science · 1994 · 2.7K citations

, , +13

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

Joël Raingeaud, Shashi Kumar Gupta, Jeffrey S. Rogers et al. · Journal of Biological Chemistry · 1995 · 2.2K citations · Full text

, , +17