Concepedia

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells

Esther Z. Chen, Blake A. Jacobson, Manish R. Patel, Aniekan Okon, Li Shui, Kerry Xiong, Abhishek J. Vaidya, Peter B. Bitterman, Carston R. Wagner, Robert A. Kratzke

Investigational New Drugs · 2014 · 23 citations · 29 references

DOI

Concepts

References

29

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

A. Lazaris-Karatzas, Kathleen S. Montine, Nahum Sonenberg · Nature · 1990 · 959 citations

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Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G

Nathan J. Moerke, Hüseyin Aktaş, Han Chen et al. · Cell · 2007 · 570 citations · Full text

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Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.

Roger Duncan, Susan C. Milburn, John W.B. Hershey · Journal of Biological Chemistry · 1987 · 493 citations · Full text

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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Jeremy R. Graff, Bruce W. Konicek, Thomas M. Vincent et al. · Journal of Clinical Investigation · 2007 · 379 citations · Full text

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Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

Svetlana Avdulov, Shunan Li, Van N. Michalek et al. · Cancer Cell · 2004 · 339 citations · Full text

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