The Leishmania mexicana proteasome

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

Life Sciences, Biochemistry, Immunology +14

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

Michele Pagano, Sun W. Tam, Anne M. Theodoras et al. · Science · 1995 · 1.8K citations

Life Sciences, Cell Biology, Molecular Biology +16

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Gabriel Fenteany, Robert F. Standaert, William S. Lane et al. · Science · 1995 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +15

Crystal Structure of the 20 <i>S</i> Proteasome from the Archaeon <i>T. acidophilum</i> at 3.4 Å Resolution

Jan Löwe, Daniela Stock, Bing K. Jap et al. · Science · 1995 · 1.5K citations

Humanities, Anthropology, Archaeology +17

Degradation of oxidized proteins in mammalian cells

Tilman Grune, Thomas Reinheckel, Kelvin J.A. Davies · The FASEB Journal · 1997 · 831 citations

Life Sciences, Biochemistry, Molecular Biology +17