6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT_2C Receptor Antagonist

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXT6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor AntagonistSteven M. Bromidge, Malcolm Duckworth, Ian T. Forbes, Peter Ham, Frank D. King, Kevin M. Thewlis, Frank E. Blaney, Christopher B. Naylor, Thomas P. Blackburn, Guy A. Kennett, Martyn D. Wood, and Stephen E. ClarkeView Author Information SmithKline Beecham Pharmaceuticals, Discovery Research, New Frontiers Science Park, Third Avenue, Harlow, Essex, England CM19 5AWCite this: J. Med. Chem. 1997, 40, 22, 3494–3496Publication Date (Web):October 24, 1997Publication History Received26 June 1997Published online24 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/jm970424chttps://doi.org/10.1021/jm970424crapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1012Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Antagonists,Ethers,Peptides and proteins,Receptors,Selectivity Get e-Alerts