Kevin M. Thewlis

Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A

Stephen G. Taylor, Martyn Wood, Nigel Austin et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 288 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Design and Synthesis of <i>trans</i>-<i>N</i>-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011):  A Potent and Selective Dopamine D₃ Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat

Geoffrey Stemp, Tracey Ashmeade, Clive L. Branch et al. · Journal of Medicinal Chemistry · 2000 · 129 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084):  The First Selective and Brain Penetrant 5-HT_2C Receptor Antagonist

Steven M. Bromidge, Malcolm Duckworth, Ian T. Forbes et al. · Journal of Medicinal Chemistry · 1997 · 84 citations · Full text

Medicine, Pharmacology, Neurochemistry +4

Design and Synthesis of<i>trans</i>-3-(2-(4-((3-(3-(5-Methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro- 1<i>H</i>-3-benzazepine (SB-414796):  A Potent and Selective Dopamine D₃Receptor Antagonist

Gregor J. Macdonald, Clive L. Branch, Michael S. Hadley et al. · Journal of Medicinal Chemistry · 2003 · 74 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators

Simon E. Ward, Mark H Harries, Laura Aldegheri et al. · Journal of Medicinal Chemistry · 2010 · 66 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17