Synergistic induction of apoptosis by sulindac and arsenic trioxide in human lung cancer A549 cells via reactive oxygen species-dependent down-regulation of survivin

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

Grazia Ambrosini, Colette Adida, Dario C. Altieri · Nature Medicine · 1997 · 3.2K citations

Life Sciences, Molecular Biology, Oncology +12

Control of apoptosis and mitotic spindle checkpoint by survivin

Fengzhi Li, Grazia Ambrosini, Emily Chu et al. · Nature · 1998 · 1.9K citations

Life Sciences, Cell Biology, Molecular Biology +12

Mechanisms of action of arsenic trioxide.

Wilson H. Miller, Hyman M. Schipper, Janet Lee et al. · PubMed · 2002 · 956 citations

Medicine, Hematology, Oncology +17

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

G-Q Chen, Jing Zhu, XG Shi et al. · Blood · 1996 · 852 citations · Full text

Life Sciences, Cell Biology, Oncology +16

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

William H. Hoffman, S. Biade, Jack T. Zilfou et al. · Journal of Biological Chemistry · 2002 · 788 citations · Full text

Life Sciences, Genetics, Oncology +16