Sirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

Chunaram Choudhary, Chanchal Kumar, Florian Gnad et al. · Science · 2009 · 4K citations

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

Diabetes Management, Medicine, Diabetes +9

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

In Hye Lee, Liu Cao, Raúl Mostoslavsky et al. · Proceedings of the National Academy of Sciences · 2008 · 1.4K citations · Full text

Cell Autophagy, Mitophagy, Signal Transduction +15

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Do‐Hoon Kim, Minh Dang Nguyen, Matthew M. Dobbin et al. · The EMBO Journal · 2007 · 1.1K citations · Full text

Amyotrophic Lateral Sclerosis, Alzheimer's Disease, Molecular Neuroscience +10

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Toshiyuki Araki, Yo Sasaki, Jeffrey Milbrandt · Science · 2004 · 1.1K citations