Concepedia

Human mesenchymal stem cells are recruited to injured liver in a β1-integrin and CD44 dependent manner

Victoria Aldridge, Abhilok Garg, Nicholas Davies, David Bartlett, Janine Youster, Heather Beard, Dean Kavanagh, Neena Kalia, Jon Frampton, Patricia F. Lalor,

Hepatology · 2012 · 67 citations · 37 references

DOI

Abstract

hMSCs bind preferentially to injured liver. Rolling of hMSCs is regulated by CD29/VCAM-1, whereas CD29/CD44 interactions with VCAM-1, fibronectin, and hyaluronan on HSECs determine firm adhesion both in vitro and in vivo as demonstrated using a murine model of liver injury.

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