The Isolation of Hypertensin from the Circulating Blood of Dogs by Dialysis in an Artificial Kidney

Abstract

A vasopressor substance has been dialyzed out of the circulating blood of dogs by means of an artificial kidney. This substance is similar to hypertensin. It has been recovered from normotensive and hypotensive dogs and from animals with malignant hypertension. The method for concentration of this substance in the dialyzate is described and concentration data which, due to the loss in recovery, is only roughly quantitative, is given.