Stereoselective synthesis of 2-aryloxy esters: An asymmetric approach to fluoxetine, tomoxetine and nisoxetine

Enantioselective and practical syntheses of R- and S-fluoxetines

E. J. Corey, Gregory A. Reichard · Tetrahedron Letters · 1989 · 188 citations

Pharmacy, Chemistry, Medicinal Chemistry +7

The absolute configurations and pharmacological activities of the optical isomers of fluoxetine, a selective serotonin-uptake inhibitor

David W. Robertson, Joseph H. Krushinski, R W Fuller et al. · Journal of Medicinal Chemistry · 1988 · 162 citations

Medicine, Medicinal Chemistry, Pharmacology +16

A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder.

PubMed · 1985 · 157 citations

Medicine, Pharmacology, Pharmacotherapy +12

Asymmetric synthesis of both enantiomers of tomoxetine and fluoxetine. Selective reduction of 2,3-epoxycinnamyl alcohol with Red-Al

Yun Gao, K. Barry Sharpless · The Journal of Organic Chemistry · 1988 · 148 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7

Chiral synthesis via organoboranes. 18. Selective reductions. 43. Diisopinocampheylchloroborane as an excellent chiral reducing reagent for the synthesis of halo alcohols of high enantiomeric purity. A highly enantioselective synthesis of both optical isomers of Tomoxetine, Fluoxetine, and Nisoxetine

Morris Srebnik, Prakash Ramachandran, Herbert C. Brown · The Journal of Organic Chemistry · 1988 · 123 citations

Natural Sciences, Chemistry, Medicinal Chemistry +7