Elevated leptin concentrations in pregnancy and lactation: Possible role as a modulator of substrate utilization

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.3K citations

Obesity, Metabolic Syndrome, Knockout Mouse +10

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Robert V. Considine, Madhur K. Sinha, Mark L. Heiman et al. · New England Journal of Medicine · 1996 · 6.3K citations

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Jeffrey L. Halaas, K.S. Gajiwala, Margherita Maffei et al. · Science · 1995 · 4.4K citations

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Mary Ann Pelleymounter, Mary Jane Cullen, Mary Baker et al. · Science · 1995 · 4K citations

Nutrition, Genetics, Adipokines +20

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

Farid Chehab, Mary E. Lim, Ronghua Lu · Nature Genetics · 1996 · 1.5K citations

Obesity, Sterility Defect, Infertility +11