A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan et al. · Cell · 2000 · 3.4K citations

Natural Sciences, Genetics, Rna Biology +7

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

Leighton J. Core, Joshua J. Waterfall, John T. Lis · Science · 2008 · 2.1K citations · Full text

Genetics, Rna Splicing, Molecular Biology +16

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Patrick Revy, Taro Muto, Yves Lévy et al. · Cell · 2000 · 1.6K citations · Full text

Mendelian Disorder, Autoimmune Disease, Genetic Disorder +8

Transcription generates positively and negatively supercoiled domains in the template

Hai-Young Wu, Shihua Shyy, James C. Wang et al. · Cell · 1988 · 750 citations

Chromatin, Transcriptional Regulation, Sequence Motif +10

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Ronda Bransteitter, Phuong Pham, Matthew D. Scharff et al. · Proceedings of the National Academy of Sciences · 2003 · 672 citations · Full text