Science · 1977 · 68 citations · 16 references
PharmacyFood ScienceToxicologyFood SafetyFood ToxicologyNutritional ToxicologyCarcinogenicity AssessmentCarcinogenicity Of Dietary ExposuresFish ToxicologyFood ContaminantsGenotoxic CarcinogenesisMutagenicity AssessmentCancer Incidence VariationFood-borne CarcinogensFoodborne CarcinogensGenotoxic Dietary ExposuresMutagenic EffectivenessMutagenic MechanismsNitrite CarcinogenicityNitrite Contamination
By the Salmonella typhimurium test, extracts of Japanese raw fish treated in the laboratory with nitrite showed mutagenic activity which is prevented by addition of ascorbate. Extracts from similarly treated beef and hot dogs were nonmutagenic. The data conform to a working concept that the high stomach cancer incidence in Japanese and certain other populations may be due to specific dietary factors of an alkylnitrosamide type.
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