Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity

The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products

Oyo Mitsunobu · Synthesis · 1981 · 4.1K citations

Natural Sciences, Biochemistry, Chemistry +8

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

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<i>Use of the Pauling Oxygen Analyzer for Measurement of Oxygen Consumption of Animals in Open-Circuit Systems and in a Short-Lag, Closed-Circuit Apparatus</i>

Florent Depocas, J. Sanford Hart · Journal of Applied Physiology · 1957 · 563 citations

Life Sciences, Physiology, Animal Physiology +12

Synthesis of Bromoacetyl Derivatives by Use of Tetrabutylammonium Tribromide

Shoji Kajigaeshi, Takaaki Kakinami, Tsuyoshi Okamoto et al. · Bulletin of the Chemical Society of Japan · 1987 · 97 citations · Full text

Natural Sciences, Chemistry, Organic Chemistry +1

Discovery of a Potent, Orally Bioavailable β₃ Adrenergic Receptor Agonist, (<i>R</i>)-<i>N</i>-[4-[2-[[2-Hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide

Robert J. Mathvink, J. Samuel Tolman, Dawn Chitty et al. · Journal of Medicinal Chemistry · 2000 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17