Concepedia

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

Valeria Di Stefano, Giovanni Blandino, Ada Sacchi, Silvia Soddu, Gabriella D’Orazi

Oncogene · 2004 · 65 citations · 35 references

DOI

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References

35

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki Miyashita, John C. Reed · Cell · 1995 · 4.1K citations · Full text

, , +12

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

, , +10

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

, , +10

A model for p53-induced apoptosis

Kornélia Polyák, Yong Xia, Jay L. Zweíer et al. · Nature · 1997 · 2.5K citations

, , +12