AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

PIK3CA is implicated as an oncogene in ovarian cancer

Laleh Shayesteh, Yiling Lu, Wen-Lin Kuo et al. · Nature Genetics · 1999 · 1.2K citations

Medicine, Molecular Genetics, Oncology +12

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

Mehran S. Neshat, Ingo K. Mellinghoff, Chris Tran et al. · Proceedings of the National Academy of Sciences · 2001 · 973 citations

Medicine, Cancer Biology, Oncology +16

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in <i>Pten</i> ^+/− mice

Katrina Podsypanina, Richard Lee, Chris Politis et al. · Proceedings of the National Academy of Sciences · 2001 · 571 citations · Full text

Medicine, Cancer Biology, Oncology +17

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

Kaname Nakatani, Devon A. Thompson, Andreas Barthel et al. · Journal of Biological Chemistry · 1999 · 474 citations · Full text

Life Sciences, Molecular Biology, Oncology +15

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

Mei Sun, Gen Wang, June E. Paciga et al. · American Journal Of Pathology · 2001 · 452 citations · Full text

Medicine, Cancer Biology, Oncology +17