Concepedia

Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours

KJ Williams, R. Cowen, M Jaffar, Mark Saunders, Rachel Airley, Davina J. Honess, A.J. van der Kogel, C. Roland Wolf

Gene Therapy · 2002 · 58 citations · 25 references

DOI

Concepts

References

25

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Thomas G. Graeber, Cynthia Osmanian, Tyler Jacks et al. · Nature · 1996 · 2.3K citations

, , +16

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

, , +14

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

Michael Höckel, Karlheinz Schlenger, Bernard Aral et al. · PubMed · 1996 · 1.7K citations

, , +13

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

David M. Brizel, Gregory S. Sibley, Leonard R. Prosnitz et al. · International Journal of Radiation Oncology*Biology*Physics · 1997 · 1.1K citations

, , +9

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

Robert A. Gatenby, Howard Kessler, Jay S. Rosenblum et al. · International Journal of Radiation Oncology*Biology*Physics · 1988 · 805 citations

, , +16