Phosphorylated p27Kip1 on Thr157 is an important prognosis in human hepatocellular carcinoma in vivo and in vitro

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Chris J. Vlahos, William F. Matter, K. Y. Hui et al. · Journal of Biological Chemistry · 1994 · 3.3K citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

The PI3K–PDK1 connection: more than just a road to PKB

Bart Vanhaesebroeck, Dario R. Alessi · Biochemical Journal · 2000 · 1.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Monoclonal antibodies against recombinant parts of the Ki‐67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave‐processed formalin‐fixed paraffin sections

Giorgio Cattoretti, Michael H. G. Becker, Göran Key et al. · The Journal of Pathology · 1992 · 1.5K citations

Life Sciences, Cell Biology, Pathology +14

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

Massimo Loda, Barry Cukor, Sun W. Tam et al. · Nature Medicine · 1997 · 1K citations

Medicine, Molecular Biology, Oncology +16

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

Jiyong Liang, Judit Zubovitz, Teresa Petrocelli et al. · Nature Medicine · 2002 · 945 citations

Life Sciences, Cell Biology, Molecular Biology +14