Long-term exposure to imatinib reduced cancer stem cell ability through induction of cell differentiation via activation of MAPK signaling in glioblastoma cells

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

Shideng Bao, Qiulian Wu, Roger E. McLendon et al. · Nature · 2006 · 6.4K citations

Medicine, Cancer Biology, Oncology +16

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Charles D. Blanke et al. · New England Journal of Medicine · 2002 · 4.4K citations · Full text

Medicine, Oncology, Pharmacology +14

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

Heidi Phillips, Samir Kharbanda, Ruihuan Chen et al. · Cancer Cell · 2006 · 3.2K citations · Full text

Medicine, Neuroscience, Oncology +16

A Tyrosine Kinase Created by Fusion of the <i>PDGFRA</i> and <i>FIP1L1</i> Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

Jan Cools, Daniel J. DeAngelo, Jason Gotlib et al. · New England Journal of Medicine · 2003 · 1.7K citations · Full text

Life Sciences, Genetics, Hematology +15

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells

Sara Piccirillo, Brent A. Reynolds, Nadia Zanetti et al. · Nature · 2006 · 1.2K citations

Medicine, Cancer Biology, Oncology +14