Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

Takashi Tsuruo, Harumi Iida, Shigeru Tsukagoshi et al. · PubMed · 1981 · 1.5K citations

Medicine, Oncology, Pharmacology +7

The multidrug transporter, a double-edged sword.

Michael M. Gottesman, I Pastan · Journal of Biological Chemistry · 1988 · 766 citations · Full text

Life Sciences, Pharmacology, Intracellular Transport +10

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

Shin‐ichi Akiyama, Antonio Tito Fojo, John A. Hanover et al. · Somatic Cell and Molecular Genetics · 1985 · 553 citations

Medicine, Genetics, Oncology +12

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

Marilyn M. Cornwell, Ira Pastan, Michael M. Gottesman · Journal of Biological Chemistry · 1987 · 535 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

Donglai Shen, Carol Cardarelli, Jinyoung Hwang et al. · Journal of Biological Chemistry · 1986 · 467 citations · Full text

Medicine, Molecular Biology, Oncology +15