Concepedia

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

Weiguo Shi, Lifeng Cai, Lu Lu, Chao Wang, Kun Wang, Liang Xu, Sha Zhang, Han Han, Xifeng Jiang, Bao-Hua Zheng,

Chemical Communications · 2012 · 18 citations · 9 references

DOI

Concepts

Abstract

Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.

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Remodeling of gp41-C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV-1 with Target Cells We thank Dr. Terrence R. Burke, Jr., NCI, NIH, Frederick, MD 21702-1201, for proofreading the manuscript and providing useful comments. This research was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, the Japan Society for the Promotion of Science, and the Japan Health Science Foundation.

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