Journal of the American Chemical Society · 2009 · 66 citations · 23 references
Natural SciencesChemistryCatalysisOrganometallic ChemistryReaction EngineeringCatalyst CharacterizationCatalyst DesignCatalyst PreparationCatalytic MaterialsCatalytic MechanismsCatalytic Reaction EngineeringCatalysis By Carbene ComplexesCatalyst Structure - Activity RelationshipsCatalytic Reaction MechanismsLigand DesignMetathesis CatalysisRing-closing MetathesisSolvent EffectsX-ray Diffraction Analysis
Two saturated N-heterocyclic carbene ligands with substituted naphthyl side chains were used for the preparation of Blechert-type ruthenium metathesis precatalysts. The resulting conformers of the complexes were separated and unambiguously assigned by X-ray diffraction studies. All new complexes were compared in terms of activity to the original, SIMes-derived Blechert catalyst and were shown to be superior. A study on the impact of solvent concentration in RCM reactions using the most active of these new catalysts ultimately led to the ring closing of a variety of substrates at very low catalyst loadings.
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