Concepedia

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Katherine L. Lee, Mark L. Behnke, Megan A. Foley, Lih-Ren Chen, Weiheng Wang, Richard Vargas, Jill Nunez, Steve Tam, Névéna Mollova, Xin Xu,

Bioorganic & Medicinal Chemistry · 2007 · 28 citations · 16 references

DOI

Concepts

References

16

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

, , +7

Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice

Hyunjung Jade Lim, Bibhash C. Paria, Sanjoy Das et al. · Cell · 1997 · 1.4K citations

, , +14

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

Robert Langenbach, Scott G. Morham, Howard F. Tiano et al. · Cell · 1995 · 1.1K citations · Full text

, , +16

Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2

Joseph V. Bonventre, Zhihong Huang, M. Reza Taheri et al. · Nature · 1997 · 845 citations

, , +11

Role of cytosolic phospholipase A2 in allergic response and parturition

Naonori Uozumi, Kazuhiko Kume, Takahide Nagase et al. · Nature · 1997 · 705 citations

, , +12