Richard Vargas

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

Katherine L. Lee, Mark L. Behnke, Megan A. Foley et al. · Bioorganic & Medicinal Chemistry · 2007 · 28 citations

Medicine, Pharmacokinetics, Pharmacology +9

Efficacy and Safety of Remdesivir in People With Impaired Kidney Function Hospitalized for COVID-19 Pneumonia: A Randomized Clinical Trial

Meghan E. Sise, José Ramón Santos, Jason D. Goldman et al. · Clinical Infectious Diseases · 2024 · 17 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacotherapy +13

Abstract 2306: BLU-222, an investigational, potent, and selective CDK2 inhibitor, demonstrated robust antitumor activity in <i>CCNE1</i>-amplified ovarian cancer models

Victoria E. Brown, Phil Ramsden, Nealia C. House et al. · Cancer Research · 2022 · 12 citations

Medicine, Oncology, Pharmacology +17