Effects of γ-20811, a long-lasting thromboxane synthetase inhibitor, on thromboxane production and platelet function

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

Ryszard J. Gryglewski, Stuart Bunting, Salvador Moncada et al. · Prostaglandins · 1976 · 1K citations

Medicine, Cardiology, Hematology +13

A Randomized Trial of Aspirin and Sulfinpyrazone in Threatened Stroke

New England Journal of Medicine · 1978 · 960 citations

Medicine, Pharmacology, Pharmacotherapy +14

A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction

P C Elwood, Alexandra Cochrane, M L Burr et al. · BMJ · 1974 · 519 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16