Vitamin E activates gene expression via the pregnane X receptor

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Medicine, Molecular Biology, Pharmacology +14

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

Nobuyuki Marui, M K Offermann, Robert A. Swerlick et al. · Journal of Clinical Investigation · 1993 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 938 citations

Medicine, Pharmacology, Toxicology +17

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

Heidi R. Kast-Woelbern, Bryan Goodwin, Paul T. Tarr et al. · Journal of Biological Chemistry · 2002 · 908 citations · Full text

Medicine, Molecular Biology, Pharmacology +17