Biopolymers · 2002 · 26 citations · 9 references
Natural SciencesChemistryPharmaceutical AnalysisAnalytical ChemistrySpectroscopic AnalysisSpectroscopyInfrared SpectroscopyInstrumental AnalysisNear-infrared SpectroscopyOptical SpectroscopySpectroscopic Analysis Of PharmaceuticalsChemometric AnalysisData ProcessingDirect MeasurementFourier Transform Infrared SpectroscopyInfrared SpectraPartial Least Squares RegressionPrincipal Component RegressionSpectroscopic Drug Analysis
Abstract A diffuse reflectance IR Fourier transform IR spectrometry (DRIFTS) method was developed for the rapid, direct measurement of mebendazole in drugs. Conventional KBr spectra and DRIFTS spectra were compared for the best determination of the active substance in the drug formulations. Two chemometric approaches were used in the data processing: multicomponent partial least squares (PLS2) and principal component regression. The best results were obtained with the PLS2 method. © 2002 John Wiley & Sons, Inc. Biopolymers (Biospectroscopy) 67: 56–60, 2002; DOI 10.1002/bip.10041
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Paul Geladi, Bruce R. Kowalski · Analytica Chimica Acta · 1986 · 6.9K citations
Polymorphism in pharmaceutical solids
F. Giordano · Journal of Controlled Release · 2001 · 676 citations
The Journal of the American Pharmaceutical Association (1912) · 1923 · 70 citations · Full text