Concepedia

The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening

Peter Vella, Waleed M. Hussein, Eleanor W. W. Leung, Daniel Clayton, David L. Ollis, Nataša Mitić, Gerhard Schenk, Ross P. McGeary

Bioorganic & Medicinal Chemistry Letters · 2011 · 72 citations · 26 references

DOI

Concepts

References

26

Discovering High-Affinity Ligands for Proteins: SAR by NMR

Suzanne B. Shuker, Philip J. Hajduk, Robert Meadows et al. · Science · 1996 · 2K citations

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Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?

D. M. Livermore · Clinical Infectious Diseases · 2002 · 1.4K citations

, , +17

Fragment-Based Lead Discovery Using X-ray Crystallography

Michael J. Hartshorn, Christopher W. Murray, Anne Cleasby et al. · Journal of Medicinal Chemistry · 2004 · 423 citations

, , +16

Standard Numbering Scheme for Class B β-Lactamases

Moreno Galleni, Josette Lamotte‐Brasseur, Gian María Rossolini et al. · Antimicrobial Agents and Chemotherapy · 2001 · 407 citations · Full text

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Identification of <i>N</i>-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1<i>H</i>-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design

Paul G. Wyatt, Andrew Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2008 · 341 citations · Full text

, , +17