Identification of IFN-γ-Producing Cells in IL-12/IL-18-Treated Mice

Cloning of a new cytokine that induces IFN-γ production by T cells

Haruki Okamura, Hiroko Tsutsui, Toshinori Komatsu et al. · Nature · 1995 · 2.6K citations

Immune Cell Development, Immunology, Immune Regulation +10

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

Giorgio Trinchieri · Blood · 1994 · 1.1K citations · Full text

Inflammation, Cytokine, Autoimmune Disease +13

IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production.

Tomohiro Yoshimoto, Kiyoshi Takeda, Takashi Tanaka et al. · PubMed · 1998 · 774 citations

T-regulatory Cell, Immunology, Immune Regulation +19

Important Advances in Oncology

Vincent T. DeVita, S Hellman, S A Rosenberg · Anti-Cancer Drugs · 1991 · 762 citations

Important Advances, Medicine, Cancer Management +6

Inhibition of Angiogenesis In Vivo by Interleukin 12

Emile E. Voest, B. M. Kenyon, M. OʼReilly et al. · JNCI Journal of the National Cancer Institute · 1995 · 727 citations