The Haystack Is Made of Needles

Clinical research for rare disease: Opportunities, challenges, and solutions

Robert C. Griggs, Mark L. Batshaw, Mary Dunkle et al. · Molecular Genetics and Metabolism · 2008 · 390 citations · Full text

Clinical Population, Clinical Studies, Clinical Trials +3

Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record

Marylyn D. Ritchie, Joshua C. Denny, Dana C. Crawford et al. · The American Journal of Human Genetics · 2010 · 326 citations · Full text

Genome-wide Association Study, Disease Heterogeneity, Epidemiology +13

From consent to institutions: Designing adaptive governance for genomic biobanks

Kieran C. O’Doherty, Michael Burgess, Kelly Edwards et al. · Social Science & Medicine · 2011 · 162 citations

Public Policy, Regulatory Approval, Engineering +13

New Models for Large Prospective Studies: Is There a Better Way?

Teri A. Manolio, Brenda K. Weis, Catherine C. Cowie et al. · American Journal of Epidemiology · 2012 · 141 citations · Full text

“The Promise of Community-Based Advocacy and Education Efforts for Increasing Cancer Clinical Trials Accrual”

Margo Michaels, Elisa S. Weiss, John A. Guidry et al. · Journal of Cancer Education · 2011 · 64 citations

Community Development, Cancer Literacy, Health Policy +13