Nucleosides Nucleotides & Nucleic Acids · 2001 · 14 citations · 10 references
Life SciencesBiochemistryMolecular BiologyBioorthogonal ChemistryEnzymologyDna StructureNucleic Acid CleavageNucleic Acid SynthesisOligonucleotide ChemistryChemical Modification Of OligonucleotidesOligonucleotide SynthesisPhosphoramidate OligonucleotidesPhosphoramidite ChemistryPhosphorothioate Oligonucleotide Synthesis
The synthesis of phosphoramidites containing 7-deazaguanine, 7-deazaadenine, uracil and cytosine carrying aminopropargyl chains is described. The corresponding oligonucleotides are stabilized in duplexes thermally as well as against degradation by exonucleases.
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