The Thr92Ala 5′ Type 2 Deiodinase Gene Polymorphism Is Associated with a Delayed Triiodothyronine Secretion in Response to the Thyrotropin-Releasing Hormone–Stimulation Test: A Pharmacogenomic Study - Concepedia

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The Thr92Ala 5′ Type 2 Deiodinase Gene Polymorphism Is Associated with a Delayed Triiodothyronine Secretion in Response to the Thyrotropin-Releasing Hormone–Stimulation Test: A Pharmacogenomic Study

DOI Full Paper Access

62

Citations

23

References

2010

Year

Peter Butler, Susan M. Smith, Joyce D. Linderman, Robert J. Brychta, Anna Teresa Alberobello, Ornella Dubaz, Javier A. Luzon, Monica C. Skarulis, Craig Cochran, Robert Wesley,

Abstract

The commonly occurring Thr92Ala D2 variant is associated with a decreased rate of acute TSH-stimulated T3 release from the thyroid consistent with a decrease in intrathyroidal deiodination. These data provide a proof of concept that the Thr92Ala polymorphism is associated with subtle changes in thyroid hormone homeostasis.

References

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