Willem Klootwijk

Polymorphisms in Thyroid Hormone Pathway Genes Are Associated with Plasma TSH and Iodothyronine Levels in Healthy Subjects

Robin P. Peeters, Hans van Toor, Willem Klootwijk et al. · The Journal of Clinical Endocrinology & Metabolism · 2003 · 246 citations · Full text

Life Sciences, Endocrinology, Genetics +14

Substitution of Cysteine for Selenocysteine in the Catalytic Center of Type III Iodothyronine Deiodinase Reduces Catalytic Efficiency and Alters Substrate Preference

George G. J. M. Kuiper, Willem Klootwijk, Theo J. Visser · Endocrinology · 2003 · 84 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Characterization of Recombinant Xenopus laevis Type I Iodothyronine Deiodinase: Substitution of a Proline Residue in the Catalytic Center by Serine (Pro132Ser) Restores Sensitivity to 6-Propyl-2-Thiouracil

George G. J. M. Kuiper, Willem Klootwijk, Ghislaine Morvan-Dubois et al. · Endocrinology · 2006 · 50 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Characteristics and Thyroid State-Dependent Regulation of Iodothyronine Deiodinases in Pigs

Frank W. J. S. Wassen, Willem Klootwijk, Ellen Kaptein et al. · Endocrinology · 2004 · 36 citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

Substitution of Cysteine for a Conserved Alanine Residue in the Catalytic Center of Type II Iodothyronine Deiodinase Alters Interaction with Reducing Cofactor

George G. J. M. Kuiper, Willem Klootwijk, Theo J. Visser · Endocrinology · 2002 · 30 citations

Life Sciences, Biochemistry, Molecular Biology +17