A convenient synthesis of 5-deaza nonclassical antifolates: Reaction of cyanothioacetamide with sodium salts of 2-(hydroxymethylene)-1-cycloalkanones

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine

E. M. GRIVSKY, Shuliang Lee, Carl W. Sigel et al. · Journal of Medicinal Chemistry · 1980 · 359 citations

Medicine, Medicinal Chemistry, Pharmacology +8

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

Edward C. Taylor, Peter J. Harrington, Stephen R. Fletcher et al. · Journal of Medicinal Chemistry · 1985 · 148 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +5

Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines

Edward F. Elslager, Judith L. Johnson, Leslie M. Werbel · Journal of Medicinal Chemistry · 1983 · 80 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Synthesis and biological activity of L-5-deazafolic acid and L-deazaaminopterin: synthetic strategies to 5-deazapteridines

Edward C. Taylor, David C. Palmer, Thomas J. George et al. · The Journal of Organic Chemistry · 1983 · 73 citations

Natural Sciences, Medicinal Chemistry, Pharmacology +8

Inhibition of dihydrofolate reductase from bacterial and vertebrate sources by folate, aminopterin, methotrexate and their 5-deaza analogues

Stuart R. Stone, John A. Montgomery, John F. Morrison · Biochemical Pharmacology · 1984 · 51 citations

Life Sciences, Biochemistry, Pharmacology +11