Evaluation of the Rabbit Purkinje Fibre Assay as an in vitro Tool for Assessing the Risk of Drug-Induced Torsades de Pointes in Humans

Cardiac Electrophysiology: From Cell to Bedside

Annals of Internal Medicine · 1991 · 2.4K citations

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Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports

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Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic

Luc M. Hondeghem, Leif Carlsson, Göran Duker · Circulation · 2001 · 505 citations

Medicine, Cardiology, Pharmacology +16

Mechanism of Block and Identification of the Verapamil Binding Domain to HERG Potassium Channels

Shetuan Zhang, Zhengfeng Zhou, Qiuming Gong et al. · Circulation Research · 1999 · 369 citations

Medicine, Pharmacology, Physiology +17

A Randomized Evaluation of the Effects of Six Antipsychotic Agents on QTc, In the Absence and Presence of Metabolic Inhibition

Edmund P. Harrigan, Jeffrey Miceli, Richard Anziano et al. · Journal of Clinical Psychopharmacology · 2004 · 358 citations

Medicine, Pharmacokinetics, Pharmacology +14