Luc M. Hondeghem

Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

Luc M. Hondeghem, Dirk J. Snyders · Circulation · 1990 · 608 citations · Full text

Reduced Effectiveness, Translational Medicine, Heart Failure +15

Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic

Luc M. Hondeghem, Leif Carlsson, Göran Duker · Circulation · 2001 · 499 citations

Mechanism for Bupivacaine Depression of Cardiac Conduction

C W Clarkson, Luc M. Hondeghem · Anesthesiology · 1985 · 436 citations · Full text

Heart Rate, Cardiac Anaesthesia, Hyperpolarization (Biology) +15

Stretch-induced arrhythmias in the isolated canine ventricle. Evidence for the importance of mechanoelectrical feedback.

D. E. Hansen, Calvin Craig, Luc M. Hondeghem · Circulation · 1990 · 274 citations

Cardiac Muscle, Heart Failure, Diastolic Function +20

Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone.

Jay W. Mason, Luc M. Hondeghem, Bertram G. Katzung · Circulation Research · 1984 · 209 citations · Full text

Muscle Function, First Time Derivative, Sodium Channel Inactivation +18