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Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues

Jennifer X. Qiao, Xuhong Cheng, Joanne M. Smallheer, Robert A. Galemmo, Spencer Drummond, Donald Pinto, Daniel L. Cheney, Kan He, Pancras C. Wong, Joseph M. Luettgen,

Bioorganic & Medicinal Chemistry Letters · 2006 · 19 citations · 16 references

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Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl-<i>N</i>-[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1<i>H</i>-pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor

Mimi L. Quan, Patrick Y. S. Lam, Qi Han et al. · Journal of Medicinal Chemistry · 2004 · 189 citations · Full text

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Discovery of 1-[3-(Aminomethyl)phenyl]-<i>N</i>-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1<i>H</i>-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa

Donald Pinto, Michael J. Orwat, Shuaige Wang et al. · Journal of Medicinal Chemistry · 2001 · 172 citations · Full text

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Absence of Placental Transfer of Pentasaccharide (Fondaparinux, Arixtra®) in the Dually Perfused Human Cotyledon in vitro

C. Vergnes, F Paolucci, Teresa Nadal et al. · Thrombosis and Haemostasis · 2002 · 102 citations

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Structure-Based Design of Novel Guanidine/Benzamidine Mimics:  Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants

Patrick Y. S. Lam, Charles G. Clark, Renhua Li et al. · Journal of Medicinal Chemistry · 2003 · 96 citations · Full text

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Design and Synthesis of Isoxazoline Derivatives as Factor Xa Inhibitors. 1

Mimi L. Quan, Ann Y. Liauw, Christopher D. Ellis et al. · Journal of Medicinal Chemistry · 1999 · 80 citations · Full text

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