Real-time, Image-Guided, Convection-Enhanced Delivery of Interleukin 13 Bound to <i>Pseudomonas</i> Exotoxin

Abstract

IL13-PE can be delivered safely and effectively to the primate brainstem at therapeutic concentrations and over clinically relevant volumes using convection-enhanced delivery. Moreover, the distribution of IL13-PE can be accurately tracked by co-infusion of Gd-albumin using real-time magnetic resonance imaging.