The role of a low ?1-adrenoceptor selectivity of [3H]CGP-12177 for resolving subtype-selectivity of competitive ligands

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

A. De Léan, Arthur A. Hancock, Robert J. Lefkowitz · Molecular Pharmacology · 1982 · 594 citations

Medicine, Pharmacology, Molecular Pharmacology +14

Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes.

David Heron, Meir Shinitzky, Moshe Hershkowitz et al. · Proceedings of the National Academy of Sciences · 1980 · 440 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

The kinetics of competitive radioligand binding predicted by the law of mass action.

Harvey Motulsky, L C Mahan · Molecular Pharmacology · 1984 · 419 citations

Medicine, Chemistry, Pharmacology +17

(�)[125Iodo]cyanopindolol, a new ligand for ?-adrenoceptors: Identification and quantitation of subclasses of ?-adrenoceptors in guinea pig

G�nter Engel, Daniël Hoyer, R. Berthold et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 1981 · 390 citations

Medicine, Pharmacology, Biochemical Pharmacology +7

CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.

M. Staehelin, Peter C. Simons, K Jaeggi et al. · Journal of Biological Chemistry · 1983 · 291 citations · Full text

Medicine, Biochemistry, Pharmacology +8