Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Psychiatric and Substance Use Comorbidity Among Treatment-Seeking Opioid Abusers

Robert K. Brooner · Archives of General Psychiatry · 1997 · 754 citations

Nursing, Behavioral Sciences, Psychiatry +17

The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research

Allan V. Kalueff, Pentti Tuohimaa · Journal of Neuroscience Methods · 2004 · 284 citations

Nursing, Behavioral Sciences, Neuroscience +15

Physiological parameters of morphine dependence in man—Tolerance, early abstinence, protracted abstinence

William R. Martin, Donald R. Jasinski · Journal of Psychiatric Research · 1969 · 265 citations

Medicine, Pharmacology, Pharmacotherapy +14

A 2.5-Year Follow-up of Depression, Life Crises, and Treatment Effects on Abstinence Among Opioid Addicts

Thomas R. Kosten · Archives of General Psychiatry · 1986 · 232 citations

Nursing, Psychiatry, Psychology +13