Brigitte L. Kieffer

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

Dominique Filliol, Sandy Ghozland, Johanna Chluba et al. · Nature Genetics · 2000 · 668 citations

Life Sciences, Neurobiology, Neuroscience +13

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

Grégory Scherrer, Noritaka Imamachi, Yuqing Cao et al. · Cell · 2009 · 452 citations · Full text

Medicine, Neurobiology, Pharmacology +16

Deficit in Attachment Behavior in Mice Lacking the µ-Opioid Receptor Gene

Anna Moles, Brigitte L. Kieffer, Francesca R. D’Amato · Science · 2004 · 447 citations

Life Sciences, Neuroscience, Psychology +17

Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal

Frédéric Simonin, Olga Valverde, Claire Smadja et al. · The EMBO Journal · 1998 · 413 citations

Medicine, Pharmacology, Molecular Pharmacology +16