Concepedia

Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities

Mohamed Ashraf Ali, Ang Chee Wei, Tan Soo Choon, Hasnah Osman, Keykavous Parang, Amir Nasrolahi Shirazi

Bioorganic & Medicinal Chemistry · 2013 · 57 citations · 20 references

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20

Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

Roy A. Frye · Biochemical and Biophysical Research Communications · 2000 · 1.4K citations

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Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

Tiago F. Outeiro, Eirene Kontopoulos, Stephen M. Altmann et al. · Science · 2007 · 1.1K citations · Full text

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Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1

Kevin J. Bitterman, Rozalyn M. Anderson, Haim Cohen et al. · Journal of Biological Chemistry · 2002 · 998 citations · Full text

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SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Jennifer Chen, Yungui Zhou, Sarah Mueller-Steiner et al. · Journal of Biological Chemistry · 2005 · 737 citations · Full text

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Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening

Christina M. Grozinger, Elizabeth D. Chao, Helen E. Blackwell et al. · Journal of Biological Chemistry · 2001 · 537 citations · Full text

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