Pharmacokinetic Properties of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Sandra Freier · Nucleic Acids Research · 1997 · 684 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

2′-O-(2-Methoxy)ethyl-modified Anti-intercellular Adhesion Molecule 1 (ICAM-1) Oligonucleotides Selectively Increase the ICAM-1 mRNA Level and Inhibit Formation of the ICAM-1 Translation Initiation Complex in Human Umbilical Vein Endothelial Cells

Brenda F. Baker, Sidney S. Lot, Thomas P. Condon et al. · Journal of Biological Chemistry · 1997 · 377 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding.

David A. Brown, Shin Hyeok Kang, S. M. Gryaznov et al. · Journal of Biological Chemistry · 1994 · 341 citations · Full text

Life Sciences, Molecular Biology, Cell Signaling +13

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.

Howard Sands, Lorraine J. Gorey‐Feret, Anthony J. Cocuzza et al. · Molecular Pharmacology · 1994 · 268 citations

Pharmacy, Biochemistry, Pharmacokinetics +15

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.

Paul A. Cossum, Henri Sasmor, D Dellinger et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 266 citations

Medicine, Pharmacokinetics, Pharmacology +12