Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis - Concepedia

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Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis

154

Citations

39

References

2015

Year

Adam P. Cribbs, Alan Kennedy, Henry Penn, Parisa Amjadi, Patricia Green, Jordan E. Read, Fionula M. Brennan, Bernard Gregory, Richard Williams

Arthritis & Rheumatology

Abstract

This study identifies a novel mechanism of action of MTX, in which treatment of RA patients with MTX restores defective Treg cell function through demethylation of the FOXP3 locus, leading to a subsequent increase in FoxP3 and CTLA-4 expression.

References

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