Antimicrobial Agents and Chemotherapy · 2015 · 13 citations · 14 references
Life SciencesMicrobiologyPharmacologyAntimicrobial PharmacotherapyAntimicrobial ResistanceMedical MicrobiologyAntibiotic ResistanceGastrointestinal InfectionsGastrointestinal PharmacologyGut MicrobiomeGut MicrobiotaInfectious DiarrheaAntibiotic Effects On The Gut MicrobiomeClostridial Enteric DiseaseClostridioides Difficile - Associated Diarrhea TreatmentEnteric Bacterial InfectionsEnterococciGut Microbiota DysbiosisPathogenesis Of Enteric InfectionsVancomycin-resistant Enterococci
The promotion of colonization with vancomycin-resistant enterococci (VRE) is one potential side effect during treatment of Clostridium difficile-associated diarrhea (CDAD), resulting from disturbances in gut microbiota. Cadazolid (CDZ) is an investigational antibiotic with potent in vitro activity against C. difficile and against VRE and is currently in clinical development for the treatment of CDAD. We report that CDZ treatment did not lead to intestinal VRE overgrowth in mice.
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Carles Úbeda, Ying Taur, Robert R. Jenq et al. · Journal of Clinical Investigation · 2010 · 939 citations · Full text
A Mouse Model of Clostridium difficile–Associated Disease
Xinhua Chen, Kianoosh Katchar, Jeffrey D. Goldsmith et al. · Gastroenterology · 2008 · 525 citations
Wafa N. Al‐Nassir, Ajay K. Sethi, Yuejin Li et al. · Antimicrobial Agents and Chemotherapy · 2008 · 244 citations
Michelle M. Nerandzic, Kathleen M. Mullane, Mark A. Miller et al. · Clinical Infectious Diseases · 2012 · 130 citations · Full text